Are you seeking for the best over the counter depression supplements on the market? If you answered yes, you are lucky because you have arrived at the greatest possible spot.
There are many different types of over the counter depression supplementss to choose from, so it can be tricky to decide which one is right for you. To help you make your decision, we’ve put together a list of the 10 best over the counter depression supplements on the market.
We’ve included a variety of options and price points to suit every budget and need. Whether you’re looking for a budget or the highest quality over the counter depression supplements, we’ve got you covered. So, if you’re in the market for a new over the counter depression supplements, read on for our top 10 picks.
10 Best over the counter depression supplements: Editor Recommended
Our Editor’s 10 Best over the counter depression supplements Reviews
- 5-in-1 Energy & Mood Support – One capsule combines Maca Root, Ashwagandha, Magnesium, Vitamin C, and Muira Puama to support balanced energy, calm focus, and mood stability.
- High-Potency Maca & Ashwagandha – Adaptogens that help combat occasional fatigue, promote positive mood, and support hormonal balance for women and men.
- Magnesium 200mg for Relaxation – Supports muscle function, nervous system health, and restful sleep. Ideal for adults seeking magnesium support.
- Vitamin C Antioxidant Boost – Helps protect against oxidative stress, supports immune function, and aids recovery from daily activities.
- Caffeine-Free Natural Vitality – Steady, balanced energy without jitters or crashes. Perfect for busy professionals, active adults, and those sensitive to caffeine.
- Plant-Based Energy Support – Features Ginger, Turmeric, and Rhodiola Rosea to help maintain natural daily energy.
- Metabolism Support Formula – Designed to assist with healthy metabolic function for everyday wellness
- Adaptogenic Herb Blend – Includes traditional herbs known to support balance during times of occasional stress.
- Supports Positive Well-Being – Crafted to encourage focus and a balanced mood for men and women.
- Clean Daily Supplement – 60 capsules with carefully selected ingredients, easy to add to your routine.
- About: Zahler Mastermin Suports Mood, Energy And Mental Health Support
- Benefits: Mastermind Enables You To Be The "Master Of You Mind"
- Comprehensive Formula: Contains A Unique Blend Of 5-Htp, Gaba, Sensoriol Ashwaganda And More
- Emotinal Well-Being: The Ingredients Found In Zahler Mastermind Supports Emotional Well-Being
- Made In The Usa: Manufactured And Bottled In A State Of Art Gmp Certified Facility
- Taking a serotonin and dopamine support supplement is better than taking a supplement to support only dopamine or only serotonin. This is because Dopamine (motivation and reward) and Serotonin (learning and mood) work in a delicate balance. Unlike leading alternatives, Dr Maxwell’s formula contains precursors of both dopamine and serotonin so it helps maintain normal neurotransmitter levels*
- Mood support and relaxation: Dr Maxwell’s formula provides Magnesium and Vitamin D3 to support overall well-being, mood and relaxation*
- Focus and brain support: our formula contains Ashwagandha, L-theanine and Taurine to support daily cognitive function and mental tasks*
- Great formula and value. Dr Maxwell’s 4-in-1 formula provides 1) dopamine precursors, 2) serotonin precursors, 3) nutrients for mood support & relaxation and 4) focus & brain support. If bought separately, these would cost between 60 and 110$*
- High quality, made from non-GMO, pure ingredients in a GMP and FDA-registered facility. Free from eggs, wheat, peanuts, sweeteners, shellfish and sugar. Please check the DO NOT USE section on the product label, which can be found among the product pictures*
- SUPPORTS MEMORY AND ATTENTION: Clinically shown to assist with memory recall and sharpen focus in healthy adults. A 300mg daily dose is optimized for peak results
- SUPPORTS OVERALL COGNITIVE HEALTH: Multiple studies have shown that Phosphatidylserine may help support attention and cognitive function in healthy adults
- MAY BOOST COGNITIVE PERFORMANCE: Studies have shown that Phosphatidylserine supports brain health, including memory, processing speed, and focus
- ROOTED IN QUALITY: Double Wood's Phosphatidylserine is manufactured right here in the USA from globally sourced ingredients, Non-GMO, and gluten-free
- WE BOTTLE WELLNESS: At Double Wood, we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
- ULTIMATE STRESS & MOOD SUPPORT — Ultisana STAMINA is your daily ally in managing stress, enhancing sleep quality, and promoting emotional balance, helping you feel calm and focused throughout the day. (Current batch expiration: September 2026)
- POWERFUL BLEND OF PREMIUM INGREDIENTS — Ultisana’s antioxidant and adaptogenic supplement supports stress resilience, mood stability, and overall well-being. It combines the soothing effects of adaptogens from Ashwagandha and turmeric, helping you maintain a sense of balance and calm throughout the day
- SYNERGISTIC COMBINATION OF MOOD-LIFTING BOTANICALS — Ashwagandha helps your body adapt to stress while St. John’s Wort works with 5-HTP and Vitamin B6 to support healthy serotonin and dopamine levels for improved mood balance and Vitamin B12 to help reduce fatigue and promote energy production for daily vitality
- SUPPORTS RESTFUL SLEEP — Our STAMINA antioxidant supplement contains turmeric root extract, which works well with Ashwagandha, to help regulate your stress response and melatonin production and promotes better sleep
- EASY & EFFECTIVE DOSAGE; VEGAN-FRIENDLY — We have created the ideal formula per dosage; take 1 or 2 capsules a day before a meal or as directed by your health provider. Ultisana STAMINA is non-GMO, and free from artificial additives and preservatives
- Promotes Vitality & Wellness: These natural mood balance supplements support higher energy levels, promote relaxation, and support healthy body function in men and women. Our mood support supplements are formulated by focusing on vital health that can promote mental well-being and better sleep patterns.
- Triple Nutritional Support: DHEA, Pregnenolone, and Melatonin are critical for vitality in all men and women. Our pure DHEA 25mg - Pregnenolone 25mg and Melatonin 2mg capsules are all you need to help support important functions like memory and mental focus.
- Supports Brain Function & Energy Levels: Our mood supplements for women and men are formulated with Pregnenolone, DHEA, and Melatonin which reinforces balance and well-being and may maintain healthy levels of body fat.
- Anti-Aging Benefits: Our pure DHEA 25mg supplement is a natural powerhouse, formulated with 25mg each of the Pregnenolone supplement and the Melatonin supplement, which promote more energy, and better sleep, and help with managing stress when taken regularly.
- SUPPORTS CALM, RELAXATION AND SLEEP: GABA is a inhibitory neurotransmitter that may help support healthy sleep habits
- AMINO ACID / NEUROTRANSMITTER: GABA is an amino acid that functions as a neurotransmitter in the brain to help support relaxation
- FIVE MONTH SUPPLY: Each bottle contains 300 capsules of GABA (150 servings of 1,000mg)
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's GABA are manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, they are Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
- Unleash Exceptional Potential: Sotalix Ashwagandha is an innovative supplement designed to enhance your overall well-being with an impressive of premium powder per serving.
- Unlike typical Ashwagandha supplements, the Sotalix product boasts an impressive concentration of Ashwagandha, along with a remarkable of St. John's Wort and Rhodiola Rosea.
- The Sotalix Ashwagandha: These powerful ingredients include Ashwagandha, St. John's Wort, Rhodiola Rosea, L-Theanine, and Phosphatidylserine. Additionally, Black Pepper has been added to ensure better absorption.
- 100% Natural - Safe And Effective: Sotalix Mushroom has been tested by 3rd-party labs and is free from any harmful chemicals - not contain fillers magnesium stearate, dioxides, preservatives, gluten, soy, sugar, yeast, starch, non-gmo.
- Ensuring Your Satisfaction: We take pride in producing only the highest quality supplements. Your gratification and wellness are always our top priority, which is why all of our products are created in a GMP-certified facility.
- NATURAL MOOD & FOCUS ENHANCEMENT: Formulated to support emotional balance, mental clarity, and calm energy with a synergistic blend of Mucuna Pruriens, Shatavari, Rhodiola Rosea, and Matcha Powder, helping you feel motivated and resilient throughout the day
- STRESS RELIEF & ADAPTOGEN SUPPORT: Shatavari and Rhodiola Rosea act as powerful adaptogens to promote relaxation and reduce everyday stress, while Mucuna Pruriens supports dopamine production for improved mood and cognitive function
- CALM ENERGY: Includes low-dose Matcha Powder balanced with L-Theanine for focused energy and alertness, ideal for morning routines without the crash
- FLEXIBLE DOSING FOR ALL USERS: Start with 1 capsule (sensitive users) for gentle support, take 2 capsules daily for standard benefits, or up to 3 capsules for enhanced results—ethically sourced, organic ingredients in vegan-friendly capsules
- THIRD-PARTY TESTED FOR PURITY: Every batch undergoes third-party testing to ensure the potency, purity, and quality of its natural ingredients, giving you confidence in every capsule.
Important Aspects To Consider When Buying over the counter depression supplements
Even deciding on an insignificant purchase can make you feel like choosing between the red pill or the blue one. But is the headache really worth it? Online shopping was meant to make our experience simpler, easier and enjoyable. But in reality it is quite easy to get confused on the decision which one to buy?
This is where our efforts come in! This list of over the counter depression supplements will surely save you valuable time and effort. However another question remains, what makes our compilation the best? Or on what basis you should trust this over the counter depression supplements list.
Is it virtually possible to know every detail of a product for making a perfect purchase? The answer is definitely NO, it’s not! Then how do you make the correct decision while buying over the counter depression supplements? Well, the complexity of selecting a single product from a sea of them can be simplified taking into consideration a few key metrics regarding the product.
We feed thousands of data to our AI regarding these products through advanced algorithms. Based on the relevant data i.e. brand, features, specs, ratings and reviews and many others (which are discussed below) a list of best over the counter depression supplements has been prepared by the AI.
Brand Reputation:
Branded products might seem pricey but the point is they are charging those extra bucks for reliability. Unlike many other things, trust doesn’t come cheap. 8 out of 10 times you can trust a branded one.
Unique Features:
Enough and useful features make a product purchase worthy. This is the basic criteria to be followed.
Useful Specifications:
Matching the right specs according to your need is very important and we miss no important things.
Star Ratings:
Healthy ratings indicate a good product. Highest rated products rarely disappoint users. So, we pick the best rated units on our list.
Number of Reviews:
Higher number of reviews in the shortest period of time shows the product is accepted widely by a lot of customers. Customer feedback aka customer reviews are the most insightful source of judging a product’s merit. We take serious consideration into customer reviews and total numbers while choosing them.
Ratio of Positive Reviews Against Bad:
The final rating is an average of all ratings provided by users. But we can get a deeper look at the product’s performance if we analyze the ratings on each star level.
Ranking of the Seller:
Shows the reputation of the seller. Even if you choose the correct item, a bad seller can be a big hassle. So stare clear of them.
Product Ranking in Relevant Category:
These small little details are never left out of our consideration. This is what makes our selection even more confident and authentic.
Bang for the Buck:
Spending a fortune on over the counter depression supplements is not a wise thing to do. Our every selected item should provide you the best value for the money you spent.
Selling Growth Over the Product Lifetime:
A product might have thousands of reviews and good ratings, still can be a bad choice. Once hyped products can be an outdated choice now. So, a gradual positive growth of any product indicates its reliability.
Latest Models:
Every product is perfected with every new edition. Those little improvements, upgrades and adjustments come real handy in user experience. So, we keep in mind to choose the latest ones.
Product Availability:
Unavailable product is like a dead lion. Discontinued items are surely not recommended.
Rating By Features:
There is a special segment in amazon where the product is rated according to different relevant features. This one is mostly overlooked by everyone. But we keep a keen eye on this!
Overall Versatility:
A product needs to be versatile and user friendly. Our aim is to prepare a list of best over the counter depression supplements which will serve you in a wide range.
Amazon’s Preference:
Amazon’s choice can be a factor to consider. It creates a sense of reliability among customers. We value amazon’s choice and prepare all lists keeping this fact in mind.
Conclusion:
The article detailing the best over the counter depression supplements ends here. However, the best option for each person will vary depending on their individual needs and preferences. But here, the over the counter depression supplementss we have listed above, have great features and are highly rated by customers. So, I hope that it may have helped you finalize your decision to choose the best over the counter depression supplements for you.