An arthritis pain relief medication is a pharmaceutical drug used to treat the symptoms of arthritis. It can help to reduce pain and inflammation, as well as providing other benefits such as improving mobility and flexibility. Some of the renowned brands are Voltaren, Mobic, and Aleve.
Choosing the right arthritis pain relief medication is difficult as it depends on various factors such as the type of arthritis you have, your age, and other health conditions you may have. To make it easier to find the exact arthritis pain relief medication you’re looking for, we rounded up the best arthritis pain relief medications on Amazon, according to thousands of customer reviews.
Check out our favorite arthritis pain relief medications in the list below, and keep reading for our buying guide.
Our Editor’s Best Arthritis Pain Relief Medications Reviews
- Arthritis pain relief: Acetaminophen 650mg extended release formula provides fast-acting, long-lasting relief for minor arthritis and joint pain in hands, wrists, knees, ankles, elbows, and feet; effective for up to 8 hours per dose
- Acetaminophen formula: Each caplet contains 650 mg of acetaminophen in an extended-release formula specifically designed for arthritis pain relief; effectively targets joint inflammation and discomfort while also reducing fever when needed
- Bi-layer technology: Pain relief pills feature a dual-layer design—first layer releases fast-acting acetaminophen for quick relief, second layer extends pain relief for up to 8 hours; gentle on the stomach for comfort
- Safe & trusted: Aspirin-free, OTC pain relief pills are suitable for adults 18+; safe when used as directed and gentle on the stomach
- Product details: Each bottle contains 100 extended-release caplets of acetaminophen 650mg; country of origin: USA; pain relief pills are aspirin-free and designed for effective, long-lasting arthritis pain relief
- Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
- HEMP SEED OIL: our Hempvana Arthritis Pain Gel is enriched with ultra-moisturizing Hemp Seed Oil
- ULTRA-STRENGTH: to give you powerful relief from inflammation, swelling, and stiffness caused by arthritis
- TARGET THE PAIN: our Ultra-Strength Relief Gel targets pain right where it hurts, like your hands, fingers, and wrists. Plus other arthritic joints
- UNIQUE FORMULA: made with 100% pure cold-pressed hemp seed oil and FDA-listed pain-fighting menthol for active pain relief
- NON-GREASY: Unlike other ointments that leave a greasy mess, Hempvana is non-greasy and absorbs quickly
- ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
- PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
- TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
- ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
- PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
- Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting arthritis pain relief, as well as relief from muscular aches, backache, menstrual cramps, headache, toothache, and the common cold
- Easy Open Arthritis Cap: Specially designed arthritis bottle features an easy to open, cushionedcovered cap and contoured bottle for better control when your arthritis acts up. Package is not child-resistant
- Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
- Targeted Pain Relief: naproxen sodium relieves minor pain from arthritis
- Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
- One 5.3 oz/150 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
- One 1.7 oz/50 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
- Number 1 Doctor Recommended topical pain relief brand
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
- Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
- ASPIRIN FOR DOGS: Nutri-Vet Aspirin for Dogs is formulated to keep your furry friend happy and active; Specifically designed for medium to large breeds, these tablets provide temporary pain relief for dogs and reduce inflammation
- ARTHRITIS AND JOINT CARE: Unleash the true power of dog pain relief; Our aspirin is specially formulated to ease arthritis and joint pain; Embrace a lifestyle of comfort and agility with dog arthritis pain relief; Your pet's wellness is our priority
- GREAT TASTE: Our canine aspirin tablets come with an irresistible liver flavor that dogs love; Our tablets combine the benefits of dog pain medicine with a taste that will make medication time a delightful experience for both you and your pet
- VETERINARIAN FORMULATED: This aspirin for dogs is carefully crafted by trusted veterinarians to ensure safe, effective relief; Made with your pet’s well-being in mind, it meets high standards for quality and helps manage minor aches and discomfort
- MADE IN THE USA: Proudly made in the USA with premium globally sourced ingredients, our tablets carry the National Animal Supplement (NASC) quality seal; We offer dog pain relief, dog supplements, and joint pain relief that symbolize quality and care
- Fast & continuous arthritis pain relief: Extended-release caplets with bi-layer design deliver an immediate-release first layer for rapid 650mg acetaminophen action and a sustained second layer for up to 8 hours overnight comfort.
- Powerful 650mg acetaminophen extended release: Each bi-layer caplet delivers proven pain relief and fever reduction to temporarily ease minor aches and pains due to arthritis, backache, headache, toothache, common cold, and menstrual cramps.
- Stomach-friendly non-aspirin formula: Tylenol caplets contain no NSAIDs and are gentle on your stomach while providing effective relief; OTC brand for safe arthritis and joint pain control when used as directed.
- Broad spectrum arthritis and pain relief: Adults 18+ can use one caplet to temporarily ease joint pain in hands, wrists, knees, ankles, elbows, and feet, as well as backache, headache, toothache, menstrual cramps, and cold symptoms.
- Dosage & safety guidelines: Take one caplet every 8 hours as needed; do not exceed four caplets in 24 hours. Consult a healthcare professional if pain persists more than two days, or before use if on blood thinners or other medications.
- NSAID-FREE ARTHRITIS RELIEF: Experience relief from arthritis pain without the use of NSAIDs. Arnicare Arthritis Pain Relief Tablets are formulated with Arnica and other pure active ingredients to provide relief for minor joint pain and stiffness.* For added relief, pair with Arnicare Arthritis Cream.
- MELT AWAY JOINT PAIN: Designed to be taken at the first signs of a flare, Arnicare Arthritis Pain Relief Tablets melt in your mouth without the need for food or water. Simply let the tablets dissolve in your mouth to experience relief from the minor aches and pain of arthritis.
- HELP YOUR BODY THE NATURAL WAY: Arnicare Arthritis Pain Relief Tablets have no known interactions with other medications or supplements and no contraindications. Gluten-free and no artificial sweeteners, flavors, colors, or preservatives.
- A TRUSTED BRAND: With over 90 years of expertise, Boiron is the Arnica expert whose Arnicare line is the #1 homeopathic Arnica pain relief brand. Boiron medicines are made in FDA-inspected facilities and meet the highest standards of cGMP and HPUS for purity and quality.
- BUY WITH HSA/FSA: Boiron Arnicare pain relievers are HSA & FSA eligible in the U.S.
Best Arthritis Pain Relief Medications Buying Guide
Before choosing the best arthritis pain relief medications you should consider following options:
1. Aspirin and Other Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs reduce inflammation by inhibiting the production of prostaglandins, chemicals your body makes to cause inflammation.
These include aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), and many others.
Aspirin is often used for its cardioprotective effects and to reduce the risk of heart attacks.
The most common side effect of NSAIDs is upset stomach and/or gastrointestinal bleeding.
NSAIDs are often used for the treatment of mild to moderate arthritis pain. They are also used for the treatment of aches and pains associated with other disorders such as muscle strains and back pain.
NSAIDs are not recommended for long-term use because they can cause kidney damage and liver damage when taken for a prolonged period of time.
2. Corticosteroids: Corticosteroids reduce inflammation by suppressing the immune system.
They are not recommended for long-term use because they can cause serious side effects, including high blood pressure and increased susceptibility to infection.
Corticosteroids are often used for the treatment of severe arthritis pain. They are also used for the treatment of other disorders where inflammation is a cause of significant pain, such as Crohn’s disease, ulcerative colitis, lupus, and others.
3. Nonsteroidal Anti-inflammatory Agents That Block COX-2: Celecoxib (Celebrex) and others belong to this group. These are used for the treatment of mild to moderate arthritis pain. The most common side effects are nausea, upset stomach, and gastrointestinal bleeding.
4. Oral Steroidal Drugs: Cortisone is one example of an oral steroid. These are used for the treatment of severe arthritis pain.
Side effects include adrenal suppression, osteoporosis, muscle weakness and thinning, glaucoma, and others.
5. Opioid Drugs: Opioids block the transmission of pain signals in the nervous system. They include hydrocodone ( Vicodin, Lortab), oxycodone (Percocet), morphine (Kadian), codeine, fentanyl (Duragesic), and others.
Common side effects of opioids include nausea, constipation, drowsiness, and addiction.
6. Topical Drugs: These reduce inflammation by cooling, drying, and reducing swelling.
Common side effects include skin irritation and burning sensation. These are often used for the treatment of back pain and other musculoskeletal disorders.
7. Corticosteroid Injections: Corticosteroid injections reduce inflammation by suppressing the immune system. These are often used for the treatment of back pain and other musculoskeletal disorders.
Side effects include infection, disc swelling, and worsening of back pain.
8. Opioid Injections: These reduce pain signals by blocking the transmission of pain signals in the nervous system. Common side effects include nausea, constipation, drowsiness, and addiction.
9. Opioid Patches: These reduce pain signals by blocking the transmission of pain signals in the nervous system. Common side effects include nausea, constipation, drowsiness, and addiction.
10. Opioid Patches with Combination NSAID and Opioid: One example of this combination is triclofed t gel. Common side
What else you should know about arthritis pain relief medications
1. What are the best arthritis pain relief medications?
There is no one-size-fits-all answer to this question, as the best arthritis pain relief medication for a particular individual may vary depending on the individual’s specific situation and health condition. However, some common arthritis pain relief medications include over-the-counter pain relievers such as acetaminophen or ibuprofen, prescription NSAIDs (non-steroidal anti-inflammatory drugs), DMARDs (disease-modifying anti-rheumatic drugs), and biologic agents.
2. What are the side effects of arthritis pain relief medications?
The side effects of arthritis pain relief medications can vary depending on the medication. Some common side effects include stomach pain, diarrhea, constipation, headache, and dizziness.
3. How do arthritis pain relief medications work?
The most common arthritis pain relief medications are anti-inflammatory drugs, which work by reducing inflammation in the joints.
4. What are the risks of taking arthritis pain relief medications?
There are a number of risks associated with taking arthritis pain relief medications, including gastrointestinal bleeding, ulcers, kidney damage, and liver damage.
5. Are there any natural arthritis pain relief medications?
There are a number of natural arthritis pain relief medications available. Some of these include omega-3 supplements, turmeric, ginger, and garlic.
Conclusion
On the market, there are numerous best arthritis pain relief medications. Hopefully, the list of the top ten best arthritis pain relief medications will save you time researching and deciding on the best one for you.