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You are here: Home / Reviews / Best Arthritis Pain Relief Medications

Best Arthritis Pain Relief Medications

An arthritis pain relief medication is a pharmaceutical drug used to treat the symptoms of arthritis. It can help to reduce pain and inflammation, as well as providing other benefits such as improving mobility and flexibility. Some of the renowned brands are Voltaren, Mobic, and Aleve.

Choosing the right arthritis pain relief medication is difficult as it depends on various factors such as the type of arthritis you have, your age, and other health conditions you may have. To make it easier to find the exact arthritis pain relief medication you’re looking for, we rounded up the best arthritis pain relief medications on Amazon, according to thousands of customer reviews.

Check out our favorite arthritis pain relief medications in the list below, and keep reading for our buying guide.

# Preview Product Price
1 Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No Prescription Needed - 1.7 oz/50 g Tube Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No... $10.98Amazon Prime Buy on Amazon
2 Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2 Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy... $31.97Amazon Prime Buy on Amazon
3 Tylenol 8 Hour Arthritis Pain Tablets with 650 mg Acetaminophen for Arthritis & Joint Pain, 100 ct Tylenol 8 Hour Arthritis Pain Tablets with 650 mg Acetaminophen for Arthritis & Joint Pain, 100 ct $12.47Amazon Prime Buy on Amazon
4 T-Relief Extra Strength Arthritis Pain Reliever Arnica +12 Natural Medicines for Joint Soreness Stiffness Aches, Quick Dissolving Pain Relief for Women & Men - 100 Tablets T-Relief Extra Strength Arthritis Pain Reliever Arnica +12 Natural Medicines for Joint Soreness... $15.99Amazon Prime Buy on Amazon
5 Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160 Count Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160... $24.87Amazon Prime Buy on Amazon
6 TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to... $22.30Amazon Prime Buy on Amazon
7 Arthritis Hot Pain Relief Creme 3 oz (Pack of 2) Arthritis Hot Pain Relief Creme 3 oz (Pack of 2) $8.99Amazon Prime Buy on Amazon
8 Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 150 g Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy... $24.68Amazon Prime Buy on Amazon
9 Hempvana Arthritis Pain Relief Gel, Ultra-Strength for Arthritis in Muscles & Joints. Enriched with Hemp Seed Oil, AS-SEEN-ON-TV. Non-Greasy. Targeted Long-Lasting Arthritis Relief. Works Fast, 4 Oz. Hempvana Arthritis Pain Relief Gel, Ultra-Strength for Arthritis in Muscles & Joints. Enriched with... $18.88Amazon Prime Buy on Amazon
10 Boiron Arnicare Arthritis Tablets for Arthritis Pain Relief, Joint Soreness, and Rheumatic Pain - 60 Count Boiron Arnicare Arthritis Tablets for Arthritis Pain Relief, Joint Soreness, and Rheumatic Pain - 60... $10.59Amazon Prime Buy on Amazon

Our Editor’s Best Arthritis Pain Relief Medications Reviews

Bestseller No. 1
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No Prescription Needed - 1.7 oz/50 g Tube
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac, No Prescription Needed - 1.7 oz/50 g Tube
  • One 1.7 oz/50 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
  • Number 1 Doctor Recommended topical pain relief brand
  • Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
  • An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
  • Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$10.98 Amazon Prime
Buy on Amazon
Bestseller No. 2
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2
  • Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
  • Number 1 Doctor Recommended topical pain relief brand
  • Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
  • An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
  • Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$31.97 Amazon Prime
Buy on Amazon
Bestseller No. 3
Tylenol 8 Hour Arthritis Pain Tablets with 650 mg Acetaminophen for Arthritis & Joint Pain, 100 ct
Tylenol 8 Hour Arthritis Pain Tablets with 650 mg Acetaminophen for Arthritis & Joint Pain, 100 ct
  • ARTHRITIS PAIN RELIEF: Tylenol 8HR Arthritis Pain Extended-Release Caplets with 650 mg acetaminophen caplets provides fast-acting, temporary relief of minor arthritis and joint pain targeted in the hands, wrists, knees, ankles, elbows, and feet.
  • ACETAMINOPHEN FORMULA: Each Tylenol 8HR Arthritis Pain relief pill contains 650 mg of acetaminophen in each caplet; For effective pain relief of minor arthritis and joint pains; Effective fever reducer.
  • Tylenol 8HR ARTHRITIS PAIN Relief PILLS: Includes 100 caplets; use 650 mg acetaminophen caplets to help provide Arthritis pain relief; The first layer of the bi-layer pill acts fast to relieve pain, and the second lasts up to 8 hours.
  • HOW To USE: Adults ages 18+, take two arthritis pain relief caplets every 8 hours while symptoms last; Do not exceed 6 capsule in 24 hours unless directed by a doctor.
  • INCLUDES: Pack of 1, 100 Tylenol 8HR Arthritis Pain Extended-Release pain relief caplets; #1 doctor recommended brand for pain relief and fever reduction; When used as directed Tylenol 8HR Arthritis Pain Relief offers an excellent safety profile.
$12.47 Amazon Prime
Buy on Amazon
Bestseller No. 4
T-Relief Extra Strength Arthritis Pain Reliever Arnica +12 Natural Medicines for Joint Soreness Stiffness Aches, Quick Dissolving Pain Relief for Women & Men - 100 Tablets
T-Relief Extra Strength Arthritis Pain Reliever Arnica +12 Natural Medicines for Joint Soreness Stiffness Aches, Quick Dissolving Pain Relief for Women & Men - 100 Tablets
  • ARTHRITIS PAIN RELIEF & BEYOND - Manage pain naturally with 13 natural active pain relievers for lasting relief of stiff, sore, joints while supporting cartilage and synovial fluid function in arthritic joints.
  • SERIOUS RELIEF FROM NATURE - Powerful pain medicine with 50% more potent plants, minerals, and tissue extracts that work fast to provide targeted relief deep in your achy joints.
  • PAIN DOESN'T HAVE TO GET IN THE WAY - Joint, back, knee or hand pain can get in the way of the activities we love; our convenient quick-dissolve tablets are easily absorbed to go to work fast and safe to use with supplements or medication.
  • BOOST YOUR BODY'S DEFENSES - Homeopathic formulas address symptoms with a micro dose of active ingredients to stimulate your body’s own defenses; we combine multiple potent actives for greater relief of more symptoms.
  • HOLISTIC APPROACH - Natural relief without risk with a safe, non-narcotic, non-addictive alternative with no known interactions; doesn't just mask pain but goes straight to the source to help stimulate your body's self-healing mechanisms.
$15.99 Amazon Prime
Buy on Amazon
Bestseller No. 5
Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160 Count
Aleve Gelcaps with Easy Open Arthritis Cap, Naproxen Sodium, Medication for Arthritis Pain, 160 Count
  • Up to 12-Hours of Uninterrupted Pain Relief: Aleve Pain Reliever & Fever Reducer Gelcaps provide long-lasting arthritis pain relief, as well as relief from muscular aches, backache, menstrual cramps, headache, toothache, and the common cold
  • Easy Open Arthritis Cap: Specially designed arthritis bottle features an easy to open, cushionedcovered cap and contoured bottle for better control when your arthritis acts up. Package is not child-resistant
  • Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
  • Targeted Pain Relief: naproxen sodium relieves minor pain from arthritis
  • Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
$24.87 Amazon Prime
Buy on Amazon
SaleBestseller No. 6
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief
TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Compared to Tylenol 8 HR Arthritis Pain Active Ingredient - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief
  • Relieve Minor Aches and Pains ... Toothache? Backache? Acetaminophen relieves minor aches and pains due to headache, backache, toothache, the common cold, minor pain of arthritis, muscular aches, and premenstrual and menstrual cramps.
  • Let That Fever Subside ... Dealing with a fever? Acetaminophen temporarily reduces fever, and relieves those aches and pains caused by minor pain of arthritis.
  • Highest Quality ... These OTC medications & treatments provide the same efficacy as your usual branded extra strength acetaminophen.
  • One in Every Medicine Cabinet ... Make sure every medicine cabinet and first-aid kit has these great pain relief tablets. 400 caplets are plenty enough to provide long-term relief for the family.
  • An Easy Way to Be Pain-Free … Find prolonged relief in a bottle of this Arthritis Pain Relief Acetaminophen 650mg. Take as directed on the bottle.
$22.30 Amazon Prime
Buy on Amazon
Bestseller No. 7
Arthritis Hot Pain Relief Creme 3 oz (Pack of 2)
Arthritis Hot Pain Relief Creme 3 oz (Pack of 2)
  • Quick-acting
  • Heating rub
  • Long-lasting relief
  • For stiffness and sore muscles.
  • NDC 41167-0600-3 (HUMAN OTC DRUG
$8.99 Amazon Prime
Buy on Amazon
Bestseller No. 8
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 150 g
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 150 g
  • One 5.3 oz/150 g tube of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
  • Number 1 Doctor Recommended topical pain relief brand
  • Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
  • An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
  • Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
$24.68 Amazon Prime
Buy on Amazon
SaleBestseller No. 9
Hempvana Arthritis Pain Relief Gel, Ultra-Strength for Arthritis in Muscles & Joints. Enriched with Hemp Seed Oil, AS-SEEN-ON-TV. Non-Greasy. Targeted Long-Lasting Arthritis Relief. Works Fast, 4 Oz.
Hempvana Arthritis Pain Relief Gel, Ultra-Strength for Arthritis in Muscles & Joints. Enriched with Hemp Seed Oil, AS-SEEN-ON-TV. Non-Greasy. Targeted Long-Lasting Arthritis Relief. Works Fast, 4 Oz.
  • HEMP SEED OIL: our Hempvana Arthritis Pain Gel is enriched with ultra-moisturizing Hemp Seed Oil
  • ULTRA-STRENGTH: to give you powerful relief from inflammation, swelling, and stiffness caused by arthritis
  • TARGET THE PAIN: our Ultra-Strength Relief Gel targets pain right where it hurts, like your hands, fingers, and wrists. Plus other arthritic joints
  • UNIQUE FORMULA: made with 100% pure cold-pressed hemp seed oil and FDA-listed pain-fighting menthol for active pain relief
  • NON-GREASY: Unlike other ointments that leave a greasy mess, Hempvana is non-greasy and absorbs quickly
$18.88 Amazon Prime
Buy on Amazon
SaleBestseller No. 10
Boiron Arnicare Arthritis Tablets for Arthritis Pain Relief, Joint Soreness, and Rheumatic Pain - 60 Count
Boiron Arnicare Arthritis Tablets for Arthritis Pain Relief, Joint Soreness, and Rheumatic Pain - 60 Count
  • Before pain gets in your way, treat it naturally at the first sign with Arnicare and feel better faster. Arnicare Arthritis Tablets are the perfect solution for those suffering from arthritis pain, specifically from stiff and swollen joints and flare-ups caused by changes in weather. Arnicare Arthritis comes in a quick-dissolving tablet form.
  • Arnica montana (or Mountain daisy) has been used for centuries as a natural pain reliever, and today, it’s one of the most popular homeopathic medicines in the world. Arnica is trusted by professional athletes to soothe sore muscles, by prominent cosmetic surgeons to relieve post-procedure pain, and by savvy moms to treat playground bumps and bruises.
  • Arnicare Arthritis's natural active ingredients help to relieve pain from stiff and inflamed joints, minor aches and pains associated with arthritis, as well as wrist, finger joint and rheumatic pain.
  • Arnicare Arthritis Tablets work naturally with your body, and there’s no risk of overdose, no contraindications, no known drug interactions, and a very low risk of side effects when used as directed.
  • At Boiron, we believe there’s more than one way to feel better. Since 1932, the Boiron family has been committed to providing quality medicines. As world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
$10.59 Amazon Prime
Buy on Amazon

Best Arthritis Pain Relief Medications Buying Guide

Before choosing the best arthritis pain relief medications you should consider following options:

1. Aspirin and Other Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs reduce inflammation by inhibiting the production of prostaglandins, chemicals your body makes to cause inflammation.

These include aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), and many others.

Aspirin is often used for its cardioprotective effects and to reduce the risk of heart attacks.

The most common side effect of NSAIDs is upset stomach and/or gastrointestinal bleeding.

NSAIDs are often used for the treatment of mild to moderate arthritis pain. They are also used for the treatment of aches and pains associated with other disorders such as muscle strains and back pain.

NSAIDs are not recommended for long-term use because they can cause kidney damage and liver damage when taken for a prolonged period of time.

2. Corticosteroids: Corticosteroids reduce inflammation by suppressing the immune system.

They are not recommended for long-term use because they can cause serious side effects, including high blood pressure and increased susceptibility to infection.

Corticosteroids are often used for the treatment of severe arthritis pain. They are also used for the treatment of other disorders where inflammation is a cause of significant pain, such as Crohn’s disease, ulcerative colitis, lupus, and others.

3. Nonsteroidal Anti-inflammatory Agents That Block COX-2: Celecoxib (Celebrex) and others belong to this group. These are used for the treatment of mild to moderate arthritis pain. The most common side effects are nausea, upset stomach, and gastrointestinal bleeding.

4. Oral Steroidal Drugs: Cortisone is one example of an oral steroid. These are used for the treatment of severe arthritis pain.

Side effects include adrenal suppression, osteoporosis, muscle weakness and thinning, glaucoma, and others.

5. Opioid Drugs: Opioids block the transmission of pain signals in the nervous system. They include hydrocodone ( Vicodin, Lortab), oxycodone (Percocet), morphine (Kadian), codeine, fentanyl (Duragesic), and others.

Common side effects of opioids include nausea, constipation, drowsiness, and addiction.

6. Topical Drugs: These reduce inflammation by cooling, drying, and reducing swelling.

Common side effects include skin irritation and burning sensation. These are often used for the treatment of back pain and other musculoskeletal disorders.

7. Corticosteroid Injections: Corticosteroid injections reduce inflammation by suppressing the immune system. These are often used for the treatment of back pain and other musculoskeletal disorders.

Side effects include infection, disc swelling, and worsening of back pain.

8. Opioid Injections: These reduce pain signals by blocking the transmission of pain signals in the nervous system. Common side effects include nausea, constipation, drowsiness, and addiction.

9. Opioid Patches: These reduce pain signals by blocking the transmission of pain signals in the nervous system. Common side effects include nausea, constipation, drowsiness, and addiction.

10. Opioid Patches with Combination NSAID and Opioid: One example of this combination is triclofed t gel. Common side

What else you should know about arthritis pain relief medications

1. What are the best arthritis pain relief medications?

There is no one-size-fits-all answer to this question, as the best arthritis pain relief medication for a particular individual may vary depending on the individual’s specific situation and health condition. However, some common arthritis pain relief medications include over-the-counter pain relievers such as acetaminophen or ibuprofen, prescription NSAIDs (non-steroidal anti-inflammatory drugs), DMARDs (disease-modifying anti-rheumatic drugs), and biologic agents.

2. What are the side effects of arthritis pain relief medications?

The side effects of arthritis pain relief medications can vary depending on the medication. Some common side effects include stomach pain, diarrhea, constipation, headache, and dizziness.

3. How do arthritis pain relief medications work?

The most common arthritis pain relief medications are anti-inflammatory drugs, which work by reducing inflammation in the joints.

4. What are the risks of taking arthritis pain relief medications?

There are a number of risks associated with taking arthritis pain relief medications, including gastrointestinal bleeding, ulcers, kidney damage, and liver damage.

5. Are there any natural arthritis pain relief medications?

There are a number of natural arthritis pain relief medications available. Some of these include omega-3 supplements, turmeric, ginger, and garlic.

Conclusion

On the market, there are numerous best arthritis pain relief medications. Hopefully, the list of the top ten best arthritis pain relief medications will save you time researching and deciding on the best one for you.

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