Are you seeking for the best supplements for stress anxiety and depression on the market? If you answered yes, you are lucky because you have arrived at the greatest possible spot.
There are many different types of supplements for stress anxiety and depressions to choose from, so it can be tricky to decide which one is right for you. To help you make your decision, we’ve put together a list of the 10 best supplements for stress anxiety and depression on the market.
We’ve included a variety of options and price points to suit every budget and need. Whether you’re looking for a budget or the highest quality supplements for stress anxiety and depression, we’ve got you covered. So, if you’re in the market for a new supplements for stress anxiety and depression, read on for our top 10 picks.
10 Best supplements for stress anxiety and depression: Editor Recommended
Our Editor’s 10 Best supplements for stress anxiety and depression Reviews
- Health Benefits - Anxie-T supports the body’s natural ability to deal with common symptoms of stress, including nervousness and nervous exhaustion, stress-related muscle tension, anxious fearfulness, and stress-related sleep problems.
- Clinically Tested Ingredients - Crafted with all natural ingredients such as Ashwagandha, Kava kava, L-theanine, and Theobromine that all work together. We even use a neurotransmitter called GABA. Its primary role in the body is thought to be the inhibition of nerve excitability.
- Effective - Most people experience the relaxing effects of Anxie-T the first day they take it, often within 30 minutes. It usually induces a feeling of calm, and won’t make you feel tired.
- Day & Night Support - Take three Anxie-T stress support supplements each morning, with or without food. An additional capsule can be added at night to support a good night’s sleep.
- One Unique Blend - Achieving a change in health requires the right ingredients in the right doses. This used to require purchasing many individual vitamins and nutrients to create an effective blend. LifeSeasons was doctor formulated to put that blend into one bottle.
- [Joy-Filled: Calm A Worried Mind] Feel more in control of your life & don't let worries and tension get in the way. Our happy pills support stress relief and promotes an overall calming effect for the mind and body. One month supply.
- [Mood Booster for Women & Men] Our ayurveda products can be the mood enhancer you're looking for. Our adaptogens formula is great for women and men looking for relaxation support and an effective stress relief supplement.
- [7 Natural Herbs] Formulated with 7 healing herbs, our powerful mood support pills are designed to help with stress. Made with Ginkgo Biloba, Rhodiola Rosea, Ashwagandha Root Powder, Lemon Balm, support your mood w/ St. John's Wort & Eleuthero Root*
- [Find Your Inner Joy] Our powerful brain and energy supplements helps increase key "feel-good" activities in your head, which are crucial components to maintaining a positive mood and avoiding unnecessary stress.
- [100% Plant-Based] Our capsules are non-GMO, vegan. The herbs are grown naturally on farms around the world so that they can be brought straight from nature's garden into your home! Try our ashwagandha pills today and enjoy a natural way to find zen.
- OLLY ULTRA STRENGTH GOODBYE STRESS ULTRA SOFTGEL: Goodbye Stress Ultra Softgels are blended with powerful botanicals and nutrients to help you stay calm and centered
- THE GOODS INSIDE: OLLY Goodbye Stress softgels are expertly blended with GABA, a fast working (within 30-60 minutes) active that supports a relaxed state of mind. L-Theanine is GABA's partner in sublime—it goes right to work in your brain to help you keep your cool, and Lemon Balm is a soothing botanical that has been used for centuries to help quiet the mind. Plus Ashwagandha for mood and energy support
- HOW TO TAKE: Take 2 softgels per day with water as needed. Swallow whole, do not chew. Comes with 60 capsules per bottle for a 30 day supply
- ULTRA SOFTGELS: Our premium Softgel blends are naturally colored, easy to swallow and have a hint of strawberry scent with zero sugar. This stress aid supplement also come in a convenient compact package.
- MIX AND MATCH: Delightful OLLY products can be taken together—mix and match as you please
- [Plant-Based Cortisol Support] Zen Again cortisol detox features KSM-66 Ashwagandha for women and men, a clinically studied adaptogen used to support healthy cortisol levels. This premium root extract helps your body manage stress naturally, promoting calm energy and daily balance without harsh stimulants or sedatives.*
- [Adaptogen Blend for Resilience] Formulated with Rhodiola Root, Panax Ginseng, and Holy Basil, Zen Again cortisol supplement for men and women helps support the body’s natural stress response. These adaptogens work synergistically to promote emotional balance, mental clarity, and energy under pressure.*
- [Promotes Relaxed Focus] L-Theanine, paired with Phosphatidylserine, helps support calm alertness without drowsiness. Whether you're working, parenting, or juggling multiple priorities, Zen Again helps you stay composed and present during everyday stress.*
- [Supports Restful Sleep] With ingredients like Magnolia Bark and L-Glycine, this formula supports a calm nighttime routine and better sleep quality. Designed for flexibility, Zen Again can be taken morning or evening—without causing next-day grogginess.*
- [Magnesium & B6 for Nerve Health] Magnesium Glycinate and Vitamin B6 play a critical role in stress regulation and neurotransmitter support. This calming mineral and essential vitamin duo helps ease tension while supporting mood stability and muscle relaxation.*
- [Stress Relief Formula] Do you get overwhelmed by daily stressors? We know the feeling! Which is why we created Zen. It's expertly curated with herbs, vitamins, and adaptogens to support your daily stressors and help you live in a zen state of mind!
- [Stay Focused and Calm] You deserve to live a happy, healthy life. That's why we combine superfoods like Passionflower & Niacinamide powder with Riboflavin and magnesium in our products so you can be more positive throughout your day!
- [Vitamins for Men and Women] Zen's vitamin supplement is a vegan daily multivitamin for women and men who want to help improve their mood. We use naturally sourced herbal ingredients to help cultivate a positive sense of well-being.
- [Premium Herbal Ingredients] WellPath Zen's calming vitamin features Ashwagandha, an Ayurvedic herb known to assist with balancing occasional stress; Rhodiola Rosea, L-Theanine, Hawthorn Leaf, Lemon Balm & more! Designed for your daily stress support
- [Featuring Ashwagandha + Rhodiola Rosea] Ashwagandha & Rhodiola Rosea are adaptogenic herbs known for their ability to help the body adapt to stress & improve energy levels.
- Manages occasional Anxiousness & Stress: Are there days you find it hard to function because you feel overwhelmed? or feeling worried or nervous? Would you like to feel like yourself again the natural way that truly works? We understand that feeling overwhelmed is one of the trending public issues that cause a magnitude of problems. Dont worry! Our Natural Calm Mood Supplement is proven and tested to nourish your body with key ingredients to promote a relaxed and happy mood.
- Powerful 28 in 1 Supplement: Doctor formulated with 28 powerful natural herbs that are scientifically proven mood enhancers used for centuries, our product aims to deliver the relief your body needs to overcome the challenges of the modern world. Our proprietary blend includes Rhodiola, Luetin, Ashwagandha, Gaba, Lemon Balm, 5-HTP, Magnesium, ST John's Wort, Vitamins B1 B2 B3 B6, Chamomile, Zinc and much more! A complete 28 in 1 Natural supplement.
- People Over Profits: Unlike other calm mood support supplements, our product aims to increase sleep & mood support twice as fast, while offering 60 days of supply for the same price as a 30 day supply brand. As a family-owned business, we take your nourishment seriously by introducing continuous innovation that makes healthy living within reach. With our plant-based Calm Mood Support Supplement, it's time to say goodbye to feeling overwhelmed and focus on living your best life today!
- A Brand That You Can Trust: Each and every batch of our proprietary Calm Mood Support Supplement is 3rd party tested to guarantee the highest purity, potency, and premium quality. Our products are manufactured under GMP certified facilities with the strictest quality control and guidelines in the USA. Without antibiotics, hormones, preservatives, artificial ingredients, chemicals, additives, soy, gluten, milk, egg, wheat, peanuts, or shellfish.
- 100% Satisfaction Guaranteed: At Rainbow Nutrients, our mission is to help people live longer, happier, and healthier lives. If for some reason, you are not satisfied with our Natural Calm Mood Support Supplement. Our products are backed by our manufacturer's 60 day money back guaranteed. Yes, you have nothing to lose. Try it, risk free!
- OLLY GOODBYE STRESS GUMMY: Calm your mind and counter bad vibes with the help of our strawberry and lemon verbena flavored gummy supplements. This stress support zen blend uses GABA and L-Theanine to help you stay calm, cool, and collected.
- THE GOODS INSIDE: Blended with GABA, a fast working active that supports a relaxed state of mind. L-Theanine is GABA's partner in sublime—it goes right to work in your brain to help you keep your cool plus Lemon Balm is a soothing botanica
- HOW TO TAKE: Chew two gummies, no food or water needed
- NATURALLY DELICIOUS: These chewable vitamins come in naturally flavored Berry Verbena made with no artificial colors or flavors and are gluten free. 42 gummies per bottle (21 day supply)
- MIX AND MATCH: Delightful and delicious OLLY products can be taken together—mix and match as you please.
- 【CORTISOL SUPPLEMENTS FOR WOMEN & MEN】 — Daily support with bacopa monnieri, ashwagandha, lemon balm, and magnolia bark to help manage stress and promote calm. A cortisol supplement for men and women seeking adrenal support, mood balance, and natural calm.
- 【BACOPA MONNIERI, ASHWAGANDHA AND L-THEANINE SUPPLEMENT 】 — This calming supplements for adults blend gaba l-theanine supplement to support ease without drowsiness. Ideal for busy minds, it includes bacopa monnieri, ashwagandha root, lemon balm and rhodiola extract for gentle, daily balance.
- 【MOOD SUPPORT SUPPLEMENT】 — Lift your spirits naturally with this mood stabilizer supplement for women and men. Featuring GABA, 5‑HTP, and lemon balm extract, it promotes emotional balance and calm confidence. Perfect as happy pills or a nerve calm supplement for clear, positive days.
- 【HERBAL CORTISOL MANAGER BLEND】 — Find your calm with a powerful blend of chamomile, passionflower, hops, magnolia bark, and skullcap. Designed as cortisol health and stress supplements for adults, this formula helps ease tension and promote restful balance—perfect for daily stress relief.
- 【STRESS VITAMINS & MINERALS】 — Capsules contain adrenal support supplements and combine rhodiola rosea, a full B-complex (B1, B2, B3, B5, B6) with magnesium. Such stress pills promote clarity, steady energy, and better stress resilience. A smart choice for those seeking stress calm supplement for women and men.
- Natural Stress Relief Gummies – Formulated with GABA, L-Theanine and Lemon Balm these delicious chewables help support natural stress relief and a calm mindset for adults and kids without causing drowsiness.
- Fast-Acting Calm Gummies – Designed to work quickly, these calming gummies for adults and kids support relaxation, focus, and balance when you need it throughout the day.
- Vegan & Allergy-Friendly Formula – Made with natural ingredients and free from gluten, dairy, soy, nuts, shellfish, and animal products—ideal for those with food sensitivities or dietary restrictions.
- Flexible Daily or As-Needed Use – Take 1–2 calming gummies daily or when occasional stress arises. This anti stress support option fits effortlessly into your wellness routine.
- No Artificial Additives or Sweeteners – These stress less gummies are crafted without artificial sweeteners, dyes, or preservatives, offering a clean way to support a relaxed state of mind.
- PhD developed stress relief & cortisol supplement: Formulated with clinically studied Sensoril Ashwagandha, Alphawave L-theanine, Vitashine Vegan Vitamin D3, Extrafolate-S Folate, and Albion Magnesium for stress relief and cortisol regulation support.*
- Reset, Relax, Unwind: Clinically tested Sensoril ashwagandha helps lower cortisol. Chelated magnesium malate guides the mind and body into a calm and relaxed state. Vitamin B Complex (B12, Folate, B6, B2) in highly absorbable and active forms support mental and cognitive health by producing neurotransmitters - serotonin and dopamine. We use Vitashine, a vegan certified Vitamin D3 made from sustainably-sourced lichen.
- Traceable Ingredients: Trace the journey behind our ingredients – You’ll see where our magnesium and ashwagandha comes from, how they are sourced and why they’re combined. Every detail meticulously on blockchain. Trust verifiable data, not just our words. ADD TO CART NOW!
- Honestly Honest: We refuse to use unnecessary additives, preservatives, and common allergens in our cortisol support supplements. We are animal-free, cruelty-free, and sustainability-forward.
- Sustainable Packaging: Our cortisol control chill pills come in a home-compostable pouch made of renewable plant materials. We are 100% plastic free. The box that houses your capsules is sourced from FSC-certified, responsibly managed, forests that provides environmental and social benefits.
Important Aspects To Consider When Buying supplements for stress anxiety and depression
Even deciding on an insignificant purchase can make you feel like choosing between the red pill or the blue one. But is the headache really worth it? Online shopping was meant to make our experience simpler, easier and enjoyable. But in reality it is quite easy to get confused on the decision which one to buy?
This is where our efforts come in! This list of supplements for stress anxiety and depression will surely save you valuable time and effort. However another question remains, what makes our compilation the best? Or on what basis you should trust this supplements for stress anxiety and depression list.
Is it virtually possible to know every detail of a product for making a perfect purchase? The answer is definitely NO, it’s not! Then how do you make the correct decision while buying supplements for stress anxiety and depression? Well, the complexity of selecting a single product from a sea of them can be simplified taking into consideration a few key metrics regarding the product.
We feed thousands of data to our AI regarding these products through advanced algorithms. Based on the relevant data i.e. brand, features, specs, ratings and reviews and many others (which are discussed below) a list of best supplements for stress anxiety and depression has been prepared by the AI.
Brand Reputation:
Branded products might seem pricey but the point is they are charging those extra bucks for reliability. Unlike many other things, trust doesn’t come cheap. 8 out of 10 times you can trust a branded one.
Unique Features:
Enough and useful features make a product purchase worthy. This is the basic criteria to be followed.
Useful Specifications:
Matching the right specs according to your need is very important and we miss no important things.
Star Ratings:
Healthy ratings indicate a good product. Highest rated products rarely disappoint users. So, we pick the best rated units on our list.
Number of Reviews:
Higher number of reviews in the shortest period of time shows the product is accepted widely by a lot of customers. Customer feedback aka customer reviews are the most insightful source of judging a product’s merit. We take serious consideration into customer reviews and total numbers while choosing them.
Ratio of Positive Reviews Against Bad:
The final rating is an average of all ratings provided by users. But we can get a deeper look at the product’s performance if we analyze the ratings on each star level.
Ranking of the Seller:
Shows the reputation of the seller. Even if you choose the correct item, a bad seller can be a big hassle. So stare clear of them.
Product Ranking in Relevant Category:
These small little details are never left out of our consideration. This is what makes our selection even more confident and authentic.
Bang for the Buck:
Spending a fortune on supplements for stress anxiety and depression is not a wise thing to do. Our every selected item should provide you the best value for the money you spent.
Selling Growth Over the Product Lifetime:
A product might have thousands of reviews and good ratings, still can be a bad choice. Once hyped products can be an outdated choice now. So, a gradual positive growth of any product indicates its reliability.
Latest Models:
Every product is perfected with every new edition. Those little improvements, upgrades and adjustments come real handy in user experience. So, we keep in mind to choose the latest ones.
Product Availability:
Unavailable product is like a dead lion. Discontinued items are surely not recommended.
Rating By Features:
There is a special segment in amazon where the product is rated according to different relevant features. This one is mostly overlooked by everyone. But we keep a keen eye on this!
Overall Versatility:
A product needs to be versatile and user friendly. Our aim is to prepare a list of best supplements for stress anxiety and depression which will serve you in a wide range.
Amazon’s Preference:
Amazon’s choice can be a factor to consider. It creates a sense of reliability among customers. We value amazon’s choice and prepare all lists keeping this fact in mind.
Conclusion:
The article detailing the best supplements for stress anxiety and depression ends here. However, the best option for each person will vary depending on their individual needs and preferences. But here, the supplements for stress anxiety and depressions we have listed above, have great features and are highly rated by customers. So, I hope that it may have helped you finalize your decision to choose the best supplements for stress anxiety and depression for you.